Biochemistry uses boronate affinity, a technique commonly used in the reversible bonding of specific molecules. This tool is valuable in a range of bioanalytical and diagnostic applications. One of these applications is in the separation and quantification of glycated haemoglobin (HbA1c) (1) found in human blood samples.
What is Boronate Affinity?
Boronate affinity is a technique commonly used in biochemistry that relies on certain boronic acid functional groups to reversibly bind to molecules such as saccharides or glycoproteins. The incredible ability of boronate affinity to bind and separate specific molecules of interest makes it a valuable tool in a range of bioanalytical and diagnostic applications. These properties make it the perfect tool for diagnosing and monitoring conditions such as diabetes.
Boronate Affinity for Glycated Haemoglobin
Glycated haemoglobin or HbA1c is an essential biomarker in the diagnosis and management of diabetes. The challenge of accurate and reliable HbA1c testing has increased due to the growing prevalence of diabetes across the globe. To address this challenge, Trinity Biotech has developed a proprietary technique using boronate affinity for the separation, quantification, and identification of glycated haemoglobin in human blood samples.
This method is known for its high sensitivity, accuracy, and specificity, which gives clients the confidence that they are receiving the most reliable test results. The innovative boronate affinity approach can help healthcare professionals diagnose and monitor diabetes accurately and reliably.
Boronate affinity is a powerful technique that has helped revolutionize the field of biomedical research. It has provided researchers with a reliable method for the detection, quantification, and isolation of compounds of interest, particularly those containing cis-diols such as sugars and glycoproteins. Boronate affinity has found widespread application in areas such as disease diagnosis, drug discovery, and glycobiology. With the constant advancement of technology and continued research, we can only expect boronate affinity to become an even more integral part of biomedical research in the future.